Ua hoʻomaka kahi hoʻokolohua lapaʻau ma ka Democratic Republic of the Congo (DRC) e loiloi i ka pono o ka antiviral drug tecovirimat (ʻike ʻia ʻo TPOXX) i nā pākeke a me nā keiki me ka monkeypox.E nānā ka hoʻokolokolo i ka palekana o ka lāʻau a me kona hiki ke hōʻemi i nā hōʻailona monkeypox a pale i nā hopena koʻikoʻi, me ka make.Ma lalo o ka PALM intergovernmental partnership, ʻo ka National Institute of Allergy and Infectious Diseases (NIAID), ʻāpana o ka National Institutes of Health, a me ka National Institute for Biomedical Research (INRB) o ka Democratic Republic of Congo e alakaʻi pū ana i ka noiʻi..ʻO nā hui hui pū me nā US Centers for Disease Control and Prevention (CDC), ka Antwerp Institute of Tropical Medicine, ka International Alliance of Health Organizations (ALIMA), a me ka World Health Organization (WHO).
Hana ʻia e ka hui lāʻau lapaʻau ʻo SIGA Technologies, Inc. (New York), ʻo TPOXX ka FDA i ʻae ʻia no ka maʻi maʻi liʻiliʻi.Hoʻopau ka lāʻau lapaʻau i ka hoʻolaha ʻana o ka maʻi i loko o ke kino, e pale ana i ka hoʻokuʻu ʻana o nā ʻāpana viral mai nā ʻāpana o ke kino.Kuhi ʻia ka lāʻau lapaʻau i kahi pūmua i loaʻa i loko o ka maʻi maʻi puupuu liʻiliʻi a me ka maʻi monkeypox.
"ʻO ka monkeypox ke kumu o ka kaumaha nui o ka maʻi a me ka make ma waena o nā keiki a me nā poʻe mākua ma ka Democratic Republic of the Congo, a ua makemake nui ʻia nā koho lapaʻau maikaʻi," wahi a NIAID Luna Hoʻokele Anthony S. Fauci, MD.ʻO ka maikaʻi o ka mālama ʻana i ka monkeypox.Makemake au e hoʻomaikaʻi i kā mākou mau hoa ʻepekema mai DRC a me Congolese no kā lākou hana mau ʻana i ka holomua ʻana i kēia noiʻi koʻikoʻi.”
Ua hoʻoulu ʻia ka maʻi ʻo Monkeypox i nā maʻi a me nā maʻi mai ka makahiki 1970, ʻo ka hapa nui ma nā wahi nahele o Central a me West Africa.Mai Mei 2022, ua hoʻomau ʻia ka maʻi maʻi multicontinental o ka monkeypox ma nā wahi i loaʻa ʻole ai ka maʻi, ʻo ia hoʻi ʻo ʻEulopa a me ʻAmelika Hui Pū ʻIa, me ka hapa nui o nā hihia i loaʻa i nā kāne e moe me nā kāne.Ua hoʻomaka ka maʻi maʻi i ka World Health Organization a me ka US Department of Health and Human Services e haʻi aku nei i kahi pilikia olakino olakino.Mai Ianuali 1, 2022 a hiki i ʻOkakopa 5, 2022, ua hōʻike ʻo WHO i 68,900 mau hihia i hoʻopaʻa ʻia a me 25 mau make ma 106 mau ʻāina, teritori a me nā teritori.
Wahi a ka World Health Organization, ʻo nā hihia i ʻike ʻia he ʻāpana o ka hoʻomau ʻana o ka honua i kumu nui ʻia e ka maʻi monkeypox Clade IIb.Ua manaʻo ʻia ʻo Clade I ke kumu o ka maʻi koʻikoʻi a ʻoi aku ka nui o ka make, ʻoi aku ka nui o nā keiki, ma mua o ka clade IIa a me ka clade IIb, a ʻo ia ke kumu o ka maʻi ma ka Demokarata Repubalika o Congo.Mai Ianuali 1, 2022 a i Kepakemapa 21, 2022, ua hōʻike ka African Centers for Disease Control and Prevention (Africa CDC) i 3,326 mau hihia o ka monkeypox (165 i hoʻopaʻa ʻia; 3,161 i manaʻo ʻia) a me 120 mau make.
Hiki i ke kanaka ke hoʻopaʻa i ka maʻi monkey ma o ka launa pū ʻana me nā holoholona i maʻi ʻia e like me nā rodents, nā primates ʻaʻole kanaka, a i ʻole nā kānaka.Hiki ke hoʻoili ʻia ka maʻi ma waena o nā kānaka ma o ka hoʻopili pololei ʻana me nā ʻili ʻili, nā wai o ke kino a me nā kulu o ka ea, me ka pili pili kokoke a me ka moe kolohe, a me ka launa pū ʻana me nā lole haumia a me nā moena.Hiki i ka Monkeypox ke hoʻoulu i nā hōʻailona like-flu a me nā ʻeha ʻili.Hiki i nā pilikia ke komo i ka wai maloʻo, ka maʻi bacteria, ka maʻi maʻi, ka mumū o ka lolo, ka sepsis, ka maʻi maka, a me ka make.
E pili ana ka hoʻāʻo ʻana a hiki i 450 mau mākua a me nā keiki me ka maʻi monkeypox i hōʻoia ʻia e ka laboratory ma ke kaupaona ʻana he 3 kg.Hiki nō hoʻi nā wāhine hāpai.E hāʻawi manawaleʻa ʻia nā poʻe hui manawaleʻa e lawe i ka tecovirimat a i ʻole placebo capsules ʻelua i kēlā me kēia lā no 14 mau lā ma ke ʻano e pili ana i ke kaumaha o ka mea komo.He makapō ʻelua ke aʻo ʻana, no laila ʻaʻole ʻike nā mea komo a me nā mea noiʻi i ka mea e loaʻa i ka tecovirimat a i ʻole placebo.
E noho nā poʻe a pau i ka haukapila no ka liʻiliʻi he 14 mau lā kahi e loaʻa ai ka mālama kākoʻo.E nānā mau nā kauka noiʻi i ke kūlana maʻi o ka poʻe komo i loko o ke aʻo ʻana a e noi i nā poʻe i komo e hāʻawi i nā laʻana koko, nā ʻāʻī ʻāʻī, a me nā ʻili ʻili no ka loiloi keʻena.ʻO ka pahuhopu nui o ke aʻo ʻana ʻo ia ka hoʻohālikelike ʻana i ka manawa manawa e ho'ōla ai i nā ʻili ʻili i nā maʻi i mālama ʻia me ka tecovirimat versus placebo.E hōʻiliʻili pū nā mea noiʻi i ka ʻikepili i kekahi mau pahuhopu lua, me ka hoʻohālikelike ʻana i ka wikiwiki o ka poʻe komo i hoʻāʻo maikaʻi ʻole no ka maʻi monkeypox i loko o ko lākou koko, ka paʻakikī a me ka lōʻihi o ka maʻi, a me ka make ma waena o nā hui.
Ua hoʻokuʻu ʻia ka poʻe i komo mai ka haukapila ma hope o ka ʻāʻī ʻana a i ʻole ka ʻili ʻana o nā maʻi āpau a ua hoʻāʻo maikaʻi ʻia no ka maʻi monkeypox i loko o ko lākou koko no ʻelua mau lā.E nānā ʻia lākou no ka liʻiliʻi o 28 mau lā a e noi ʻia e hoʻi i 58 mau lā no kahi mākaʻikaʻi koho koho no nā hoʻokolohua lapaʻau a me nā hoʻokolohua hou.E nānā ke kōmike mālama ʻikepili kūʻokoʻa a me ka palekana i ka palekana o nā poʻe komo i loko o ka wā aʻo.
Ua alakaʻi ʻia ke aʻo ʻana e ka mea noiʻi kumu nui ʻo Jean-Jacques Muyembe-Tamfum, Luna Hoʻokele o INRB a me Professor of Microbiology, Faculty of Medicine, University of Kinshasa, Gombe, Kinshasa;ʻO Placid Mbala, MD, Luna Polokalamu PALM, Poʻo o ka INRB Epidemiology Division a me ka Pathogen Genomics Laboratory.
"ʻOliʻoli wau ʻaʻole he maʻi mālama ʻole ʻia ka monkeypox a ʻaʻole koke, mahalo i kēia haʻawina, e hiki iā mākou ke hōʻike i kahi lāʻau lapaʻau kūpono no kēia maʻi," wahi a Kauka Muyembe-Tamfum.
No ka ʻike hou aku, e kipa iā Clinicaltrials.gov a e ʻimi iā ID NCT05559099.E pili ana ka papa ho'āʻo i ka helu hoʻopaʻa inoa.Ke hoʻomaka nei ka hoʻokolokolo TPOXX i kākoʻo ʻia e NIAID ma ʻAmelika Hui Pū ʻIa.No ka ʻike e pili ana i nā hoʻokolohua US, e kipa i ka pūnaewele AIDS Clinical Trials Group (ACTG) a huli iā TPOXX a i ʻole ke aʻo ʻana iā A5418.
ʻO PALM kahi acronym no "Pamoja Tulinde Maisha", he huaʻōlelo Swahili ʻo ia hoʻi "hoʻopakele ola pū".Ua hoʻokumu ʻo NIAID i kahi hui noiʻi noiʻi PALM me ka DRC Ministry of Health i ka pane ʻana i ka 2018 Ebola outbreak ma DRC hikina.Ke hoʻomau nei ka hui ʻana ma ke ʻano he papahana noiʻi lapaʻau multilateral e pili ana i ka NIAID, DRC Health Department, INRB a me nā hoa INRB.ʻO ka haʻawina PALM mua he hoʻāʻo i hoʻopaʻa ʻia i nā lāʻau lapaʻau he nui no ka maʻi maʻi Ebola i kākoʻo i ka ʻae kānāwai o NIAID-developed mAb114 (Ebanga) a me REGN-EB3 (Inmazeb, hoʻomohala ʻia e Regeneron).
Ke alakaʻi a kākoʻo nei ʻo NIAID i ka noiʻi ma NIH, ʻAmelika Hui Pū ʻIa, a puni ka honua e hoʻomaopopo i nā kumu o nā maʻi lele a me ka pale ʻana i nā maʻi a me ka hoʻomohala ʻana i nā ala maikaʻi e pale ai, ʻike, a mālama i kēia mau maʻi.Loaʻa nā palapala hoʻolaha, nā nūhou, a me nā mea pili i ka NIAID ma ka pūnaewele NIAID.
E pili ana i ka National Institutes of Health (NIH): ʻO ka National Institutes of Health (NIH) he hale noiʻi lapaʻau o ʻAmelika Hui Pū ʻIa o 27 mau kula a me nā kikowaena a he ʻāpana ia o ka US Department of Health and Human Services.ʻO ka NIH ke keʻena federal mua e alakaʻi a kākoʻo i ka noiʻi lapaʻau kumu, lapaʻau, a me ka unuhi ʻana, e noiʻi ana i nā kumu, nā lāʻau lapaʻau, a me nā lāʻau lapaʻau no nā maʻi maʻamau.No ka 'ike hou aku e pili ana i ka NIH a me kāna mau papahana, e kipa www.nih.gov.
Ka manawa hoʻouna: ʻOkakopa-14-2022
